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PROF. A. SOWUNMI

PROF. A. SOWUNMI

CURRICULUM VITAE

  1. Name Sowunmi Akintunde

Date of Birth     19 November 1954

Departments   1.  Pharmacology & Therapeutics, University of Ibadan, Ibadan,

Nigeria.

e-mail: malaria.iba@alpha.linkserve.com; akinsowunmi@hotmail.com

Fax: +234 2 2411843  Tel: 234 2 2412101, 234 2 2411904

 

  1. Academic qualifications (with Dates and Granting Bodies)

MB, BS.    July 1978, University of Ibadan, Ibadan

M.Sc.        November 1982, University of Ibadan, Ibadan

  1. December 1993, University of Ibadan, Ibadan

 

  1. Professional qualifications and Diplomas

FRCPI.  March 2005.  (Royal College of Physicians of Ireland, Ireland)

FRCPath.  March 2004 (The Royal College of Pathologists, UK)

FWACP.  October 1988 (West African Postgraduate Medical College)

FMCP.  November 1988 (National Postgraduate Medical College of Nigeria)

 

  1. Membership of Learned Societies

Member, Federal Government ( Federal Ministry of Health) Committee for

Quantification of Drug Needs for Federal Health Institutions ( April, 1990).

Cited in Who ‘s Who in Nigeria 2 nd Edition 1999

Cited in Who’s Who in The World 14th Edition 1997.

Cited in 2000 Outstanding Scientists of the 20th Century (International Biographical

Centre, Cambridge, UK).

Cited in Dictionary of International Biography (International Biographical Centre,

Cambridge, UK).  28th Edition.

Cited in 2000 Outstanding People of the 20th Century (International Biographical

Centre, Cambridge, UK).  2 nd Edition.

Cited in 2000 Outstanding intelectuals of the 20th Century (International Biographical

Centre, Cambridge, UK).

Cited in 2000 Outstanding scholars of the 21th Century (International Biographical

Centre, Cambridge, UK).

Cited in 21st Century Leaders of Science, Technology and Engineering (American

Biographical Institute, Raleigh, NC).

Cited in 1000 World Leaders of Scientific Influence (American Biographical Institute,

Raleigh, NC).

Cited in International Personality of the Year 2001 (International Biographical Centre,

Cambridge, UK).

 

  1. Administrative appointment

Acting Head of Department of Pharmacology & Therapeutics, November 1994 -February 1998

Professor and Head of Department of Pharmacology & Therapeutics, March 1998 -February 2001, and August 2006 to date.

 

  1. Publications

Section 1: Pharmacodynamics of antimalarial drugs

Quinine and chloroquine

  1. Salako, L.A., Sowunmi, A. & Laoye, O.J. (1988). Evaluation of the sensitivity in-vivo and in-vitro of Plasmodium falciparum malaria to quinine in an area of full sensitivity to chloroquine.  Transactions of the Royal Society of Tropical Medicine & H ygiene, 82, 366-368.

 

  1. Sowunmi, A., Salako, L.A., Laoye, O.J. & Aderounmu, A.F. (1990). Combination of quinine, quinidine and cinchonine for the treatment of acute falciparum malaria: correlation with the susceptibility of Plasmodium falciparum to the cinchona alkaloids in vitro.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 84, 626-629.

 

  1. Sowunmi, A. & Salako, L.A. (1992). Evaluation of the relative efficacy of various antimalarial drugs in Nigerian children under five years of age suffering from acute uncomplicated falciparum malaria.  Annals of Tropical Medicine & Parasitology, 86, 1-8.

 

Co-trimoxazole

 

  1. Fehintola, F.A., Adedeji, A.A., Tambo, E., Fateye, B.B., Happi, T.C. & Sowunmi, A. (2004).  Cotrimoxazole in the treatment of acute uncomplicated falciparum malaria in Nigerian children: a controlled clinical trial.  Clinical Drug Investigation, 24, 149-155.

 

Sulfadoxine-pyrimethamine

  1. Salako, L.A., Adio, R.A., Sowunmi, A. & Walker, O. (1990). Parenteral sulfadoxine-pyrimethamine  (Fansidar (R)): an effective and safe but under-used method of malaria treatment.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 84, 641-643.

 

Halofantrine

  1. Salako, L.A., Sowunmi, A. & Walker, O. (1990). Evaluation of the clinical efficacy and safety of halofantrine in falciparum malaria in Ibadan, Nigeria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 84, 644-647.

 

  1. Falade, C.O., Salako, L.A., Sowunmi, A. Oduola, A.M.J. & Larcier, P. (1997). Comparative efficacy of halofantrine, chloroquine and sulpfadoxine-pyrimethamine in the treatment of acute uncomplicated falciparum malaria in Nigerian children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 91, 58-62.

 

Mefloquine

  1. Sowunmi, A., Salako, L.A., Walker, O. & Ogundahunsi, O.A.T. (1990). Clinical efficacy of mefloquine in children suffering from chloroquine-resistant Plasmodium falciparum malaria in Nigeria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 84, 761-764.

 

  1. Sowunmi, A., Oduola, A.M.J., Salako, L.A., Ogundahunsi, O.A.T., Laoye, O.J. & Walker, O. (1992). The relationship between the response of Plasmodium falciparum malaria to mefloquine in African children and its sensitivity in-vitro.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 86, 368-371.

 

  1. Oduola, A.M.J., Sowunmi, A., Milhous, W.K., Kyle, D.E., Martin, S.K., Walker, O. & Salako, L.A. (1992). Innate resistance to new antimalarial drug in Plasmodium falciparum from Nigeria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 86, 123-127.

 

  1. Sowunmi, A., Oduola, A.M.J., Ilesanmi, A.O. & Salako, L.A. (1996). Open comparison of artemether and mefloquine in uncomplicated Plasmodium falciparum hyperparasitaemia in children.  Annals of Tropical Paediatrics, 16, 5-9.

 

  1. Sowunmi, A. & Oduola, A.M.J. (1995). Open comparison of mefloquine, mefloquine-sulfadoxine-pyrimethamine and chloroquine in acute uncomplicated falciparum malaria in children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 89, 303-305.

 

  1. Sowunmi, A., Walker, O. & Akindele, J.A. (1992). Severe falciparum malaria: survival with oral therapy.  Tropical& Geographical Medicine, 44, 352-354.

 

  1. Salako, L.A., Adio, R.A., Walker, O., Sowunmi, A., Sturchler, D., Mittleholzer, M.L., Reber-Liske, R. & Dickshatt, U. (1992). Mefloquine-sulfadoxine-pyrimethamine (Fansidar(R), Roche) in the prophylaxis of Plasmodium falciparum malaria: a double-blind, comparative, placebo controlled study.  Annals of Tropical Medicine & Parasitology, 86, 575-581.

 

  1. Sowunmi, A., Salako, L.A., Oduola, A.M.J., Walker, O., Akindele, J.A. & Ogundahunsi, O.A.T. (1993). Neuropsychiatric side effects of mefloquine in Africans.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 87, 462-463.

 

  1. Sowunmi, A. (1994). Acute psychosis after mefloquine: case report.  East African Medical Journal, 71, 818-819.

 

 

  1. Sowunmi, A., Salako, L.A., Adio, R.A., Oduola, A.M.J. & Ogundahunsi, O.A.T. (1995). Acute psychosis after mefloquine: report of six cases.  Tropical & Geographical Medicine, 47, 179-180.

 

Artemether

  1. Walker, O., Salako, L.A., Omokhodion, S.I. & Sowunmi, A. (1993). An open comparative study of intramuscular artemether against intravenous quinine in cerebral malaria in children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 87, 564-566.

 

  1. Salako, L.A., Walker, O., & Sowunmi. A. (1994). Parenteral therapy of moderately severe malaria: comparison of intramuscular artemether and intramuscular sulfadoxine-pyrimethamine.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 88, 89-91.

 

  1. Salako, O., Walker, O., Sowunmi, A., Omokhodion, S.I., Adio, R.A. & Oduola, A.M.J. (1994). Artemether in moderately severe and cerebral malaria in Nigerian children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 88, supplement 1, S13-S15.

 

  1. Sowunmi, A., Oduola, A.M.J. & Salako, L.A. (1995). Artemether treatment of sulfadoxine-pyrimethamine-resistant Plasmodium falciparum malaria in children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 89, 435-436.

 

  1. Sowunmi, A. & Oduola, A.M.J. (1997). Artemether treatment of recrudescent Plasmodium falciparum malaria in children.  Tropical Medicine & International Health, 2, 631-634.

 

  1. Sowunmi, A. & Oduola, A.M.J. (1996). Efficacy of artemether in severe falciparum malaria in African children.  Acta Tropica, 61, 57-63.

 

Amodiaquine/ Combination antimalarial therapy

  1. Sowunmi, A., Ayede, A.I., Falade, A.G., Ndikum, V.N., Sowunmi, C.O., Adedeji, A.A., Falade, C.O., Happi, T.C. & Oduola, A.M.J. (2001). Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.  Annals of Tropical Medicine & Parasitology, 95, 549-558.

 

  1. Sowunmi, A. (2002). A randomized comparison of chloroquine, amodiaquine and their combination with pyrimethamine-sulfadoxine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.  Annals of Tropical Medicine & Parasitology, 96, 227-238.

 

  1. Alloueche, A., Bailey, W., Barton, S., Bwika, J., Chimpeni, P., Falade, C.O., Fehintola, F.A., Horton, J., Jaffar, S., Kanyok, T., Kremsner, P.G., Kublin, J.G., Lang, T., Missinou, M.A., Mkandala, C., Oduola, A.M.J., Premji, Z., Robertson, L., Sowunmi, A., Ward, S.A. & Winstanley, P.A. (2004). Comparison of chlorproguanil-dapsone with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in young African children.  Lancet, 363, 1843-1848.

 

  1. Sowunmi, A., Fehintola, F.A., Adedeji, A.A., Gbotosho, G.O., Tambo, E., Fateye, B.A., Happi, T.C. & Oduola, A.M.J. (2005).  Open randomized study of amodiaquine-artesunate vs. chloroquine-pyrimethamine-sulfadoxine for the treatment of uncomplicated Plasmodium falciparum malaria in Nigerian children.  Tropical Medicine and International Health, 10, 1161-1170.

 

  1. Sowunmi, A., Gbotosho, G.O., Happi, C.T., Adedeji, A.A., Fehintola, F.A., Folarin, O.A., Tambo, E & Fateye, B.A. (2007). Therapeutic efficacy and effects of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine on gametocyte carriage in children with uncomplicated Plasmodium falciparum malaria in southwestern Nigeria.  American Journal of Tropical Medicine & Hygiene, 77, 235-241.

 

  1. Premji, Z., Umeh, R.E., OwusuAgyei, S., Esamai, F., Ezedinachi, E.U., Oguche, S., Borrmann, S., Sowunmi, A., Duparc, S., Kirby, P., Pamba, A., Kellam, L., Guigumde, R., Greenwood, B., Ward, S.A. & Winstanley, P.A. (2009). Chlorproguanil-dapsone-artesunate versus artemether-lumefantrine: a randomized, double-blind Phase III trial in African children and adolescents with uncomplicated Plasmodium falciparum malaria PLoS ONE 4, e6682.  doi:10.1371/journal.pone.0006682.

 

  1. Ayede I. A., Falade A. G., Sowunmi A. & Jansen F.H. (2010). An open randomized clinical trial in comparing two artesunate-based combination treatments on Plasmodium falciparum malaria in Nigerian children: artesunate/sulphamethoxypyrazine/pyrimethamine (fixed dose over 24 hours).  Malaria J, 9:378.

 

  1. Michael O. S., Gbotosho G. O., Folarin O. A., Okuboyejo T., Sowunmi A., Oduola A. M. & Happi C. T. (2010). Early variations in Plasmodium falciparum dynamics in Nigerian children after treatment with two artemisinin-based combinations: implications on delayed parasite clearance.  Malaria J, 9, 335.

 

  1. Gbotosho G.O., Sowunmi A., Okuboyejo, T.M., Happi, C.T., Folarin O.O., & Adewoye, E.O. (2012). A simple dose regimen of artesunate and amodiaquine based on age or body weight range for uncomplicated falciparum malaria in children: comparison of therapeutic efficacy with standard dose regimen of artesunate and amodiaquine, and artemether-lumefantrine.  American Journal of Therapeutics, July. 19(4), e122-131.

 

  1. Sowunmi A., Akinrinla, I.A., Gbotosho G.O., Okuboyejo, T.M. & Happi, C.T. (2012). A simple dose regimen of artesunate and amodiaquine based on arm span or age for childhood falciparum malaria: a preliminary evaluation.  Journal of Tropical Pediatrics, 58, 263-268.

 

  1. Gbotosho G.O., Sowunmi A., Okuboyejo, T.M., Happi, C.T., Folarin O.A., Michael O.S. & Adewoye, E.O. (2011). Therapeutic efficacy of artemether-lumefantrine and artesunate-amodiaquine co-formulated or co-packaged on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in children.  American Journal of Tropical Medicine & Hygiene, 84, 813-819.

 

  1. Gbotosho G.O., Sowunmi A., Okuboyejo, T.M. & Happi. (2012). Oral artemether-lumefantrine and artesunate-amodiaquine in the treatment of uncomplicated hyperparasitaemic Plasmodium falciparum malaria in children.  Journal of Tropical Pediatrics, 58, 151-153.

 

  1. Gbotosho G.O., Sowunmi A., Happi , C.T. & Okuboyejo, T.M. (2011). Therapeutic efficacies of artemisinin-based combination therapies in Nigerian children with uncomplicated falciparum malaria during five years of adoption as first-line treatments.  American Journal of Tropical Medicine & Hygiene, 84, 936-943.

 

Vaccine

  1. Reber-Lisk, R., Salako, L.A., Matile, H., Sowunmi, A. & Sturchler, D. (1995). [NANP]19-5.1.  A malaria vaccine field trial in Nigerian children.  Tropical & Geographical Medicine, 47, 61-63.

 

Others

  1. Oduola, A.M.J., Omitowoju, G.O., Sowunmi, A., Makler, T., Falade, C.O., Kyle, D.E., Fehintola, F.A., Ogundahunsi, O.A.T., Piper, A.C., Schuster, B.G. & Milhous, W.K. (1997). Plasmodium falciparum: evaluation of lactate dehydrogenase in monitoring therapeutic responses to standard antimalarial drugs in Nigeria.  Experimental Parasitology, 87, 283-289.

 

  1. Sowunmi, A., Walker, O. & Salako, L.A. (1989). Pruritus and antimalarial drugs in Africans.  Lancet 2, 213.

 

  1. Gbotosho, G.O., Happi, C.T., Ganiyu, A., Ogundahunsi, O.A.T., Sowunmi, A. & Oduola, A.M.J. (2009).  Potential contribution of prescription practices to the emergence and spread of chloroquine resistance in south-west Nigeria: caution in the use of artemisinin based combination therapy.  Malaria J, 8, 313.

 

41  Gbotosho, G.O., Happi, C.T., Woranola, O., Abiodun, O.O., Sowunmi, A. & Oduola, A.M.J. (2012).  Interaction between ciprofloxacin and chloroquine in mice infected with chloroquine-resistant Plasmodium berghei.  Parasitology Research 110, 895-899.

 

 

Section 2: Cardiac effects of antimalarial drugs

  1. Sowunmi, A., Falade, C.O., Oduola, A.M.J., Ogundahunsi, O.A.T., Fehintola, F.A., Gbotosho, G.O., Larcier, P. & Salako, L.A. (1998). Cardiac effects of halofantrine in children suffering from acute uncomplicated falciparum malaria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 92, 446-448.

 

  1. Sowunmi, A., Fehintola, F.A., Ogundahunsi, O.A.T., Ofi, A.B., Happi, T.C. & Oduola, A.M.J. (1999). Comparative cardiac effects of halofantrine and chloroquine plus chlorpheniramine in children with acute uncomplicated falciparum malaria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 93, 78-83.

 

  1. Sowunmi, A., Falade, C.O., Adedeji, A.A., Happi, T.C., Sowunmi, C.O., Ofi, A.B., Okanlawon, F.A. & Oduola, A.M.J. (2000). Patterns of change in the electrocardiogram after halofantrine treatment of acute uncomplicated falciparum malaria in children.  Clinical Drug Investigation, 20, 229-235.

 

  1. Sowunmi, A. (2004).  Disposition kinetics of the relative increase in electrocardiographic time intervals: a novel method for the evaluation of the cardiac effects of antimalarial drugs.  Journal of Applied Therapeutic Research, 4, 27-37.

 

  1. Sowunmi, A., Adedeji, A.A. & Babalola C.P. (2005).  Randomised comparison of the cardiac effects of halofantrine and chloroquine plus chlorpheniramine in children with acute falciparum malaria using a novel method: disposition kinetics of the relative increase in electrocardiographic time intervals.  Journal of Applied Therapeutic Research, 5, 41-48.

 

 

Section: 3 Pharmacokinetics of antimalarials and effects of malaria on drug disposition

  1. Salako, L.A. & Sowunmi, A. (1992). Disposition of quinine in plasma, red blood cells and saliva after oral and intramuscular administration to healthy adult Africans.  European Journal of  Clinical Pharmacology, 42, 171-174.

 

  1. Sowunmi, A. & Salako, L.A. (1996). Effect of dose size on the pharmacokinetics of orally administered quinine.  European Journal of Clinical Pharmacology, 49, 383-386.

 

  1. Sowunmi, A. (1996). Disposition of quinine in plasma after a single oral and intramuscular dose in healthy adult Africans.  East African Medical Journal, 73, 111-114.

 

  1. Babalola, C.P., Bolaji, O.O., Ogunbona, F.A., Sowunmi, A. & Walker, O. (1997). Dose linearity of quinine in healthy human subjects.  European Journal of Pharmaceutics and Biopharmaceutics, 44, 143-147.

 

  1. Sowunmi, A., Salako, L.A. & Ogunbona, F.O. (1994). Bioavailability of the sulphate and hydrochloride salts of quinine.  African Journal of Medicine & Medical Sciences, 23, 275-278.

 

  1. Sowunmi, A. (1996). Disposition of oral quinine in African patients suffering from acute uncomplicated falciparum malaria.  East African Medical Journal, 73, 519-523.

 

  1. Babalola, C.P., Bolaji, O.O., Ogunbona, F.A., Sowunmi, A. & Walker, O. (1998). Pharmacokinetics of quinine in African patients with acute falciparum malaria.  Pharmacy World Science, 20, 118-122.

 

  1. Salako, L.A., Sowunmi, A. & Akinbami, F.O. (1989). Pharmacokinetics of quinine in African children suffering from kwashiorkor.  British Journal of Clinical Pharmacology, 28, 197-201.

 

  1. Akinyinka, O.O., Sowunmi A., Honeywell, R., & Renwick, A.G. (2000). The pharmacokinetics of caffeine in Nigerian children suffering from malaria and kwashiorkor.  European Journal of Clinical Pharmacology, 56, 153-158.

 

  1. Akinyinka, O.O., Sowunmi, A., Honeywell, R. & Renwick A.G. (2000). The effects of acute falciparum malaria on the disposition of caffeine and the comparison of saliva and plasma-derived pharmacokinetic parameters in adult Nigerians.  European Journal of Clinical Pharmacology, 56, 159-165.

 

  1. Akinyinka, O.O., Sowunmi, A., Honeywell, R. & Renwick A.G. (2000). Urinary recovery of caffeine and its metabolites in healthy African children.  African Journal of Medicine & Medical Sciences, 32, 1-4.

 

  1. Babalola, C.P., Scriba, G.K.E., Sowunmi, A. & Alawode, O.A. (2003). Liquid chromatographic determination of pyronaridine in human plasma and oral dosage form.  Journal of Chromatography B, 795, 265-272.

 

  1. Gbotosho, G.O., Happi, C.T., Sijuade, A., Sowunmi, A.,. & Oduola, A. (2009).  Pharmacokinetic disposition of sulfadoxine in children with acute uncomplicated falciparum malaria treated with sulfadoxine-pyrimethamine in south west Nigeria.  American Journal of Therapeutics, 81, Nov 14, e-pub ahead of print.

 

  1. Gbotosho, G.O., Happi, C.T., Sijuade, A.O, Sowunmi, A., & Oduola, A. (2009).  A simple cost-effective high-performance liquid chromatographic assay of sulphadoxine in whole blood spotted on filter paper for field studies.  Malaria J 8, 238.

 

  1. Sowunmi A., Gbotosho G. O., Happi C. T., Okuboyejo T. M., Sijuade A. O., Michael O. S., Adewoye E. O., & Folarin O. (2010) Therapeutic efficacy of artesunate-amodiaquine combinations and the plasma and saliva concentrations of desethylamodiaquine in children with acute uncomplicated Plasmodium falciparum malaria. American Journal of Therapeutics Epub ahead of print Feb 3, 2011.

 

  1. Gbotosho, G.O., Happi, C.T., Lawal, O., Sijuade, A., Sowunmi, A., & Oduola, A. (2012).  A high-performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans.  Malaria J 11, 59.

 

 

Section: 4 Pathophysiologic studies in children with malaria

  1. Sowunmi, A. (1996). Renal function in acute falciparum malaria.  Archives of Disease in Childhood, 74, 293-298.

 

  1. Sowunmi, A. (1996). Hyponatraemia in severe malaria: a clinical study of nineteen comatose African children.  African Journal of Medicine & Medical Sciences, 25, 47-52.

 

  1. Sowunmi, A., Newton, C.R.J.C., Waruiru, C., Lightman, S. & Dunger, D.B. (2000). Arginine vasopressin secretion in Kenyan children with severe malaria.  Journal of Tropical Paediatrics, 46, 195-199.

 

  1. Newton, C.R.J.C., Peshu, N., Kendall, B., Kirkham, F.J., Sowunmi, A., Waruiru, C., Mwangi, I. & Marsh, K. (1994). Brain swelling and ischaemia in Kenyans with cerebral malaria.  Archives of Disease in Childhood, 70, 281-287.

 

  1. Newton, C.R.J.C., Crawley, J., Sowunmi, A., Waruiru, C., Mwangi, I., English, M., Murphy, S., Winstanley, P.A. Marsh, K. & Kirkham, F.J. (1997). Intracranial hypertension in Africans with cerebral malaria.  Archives of Diseases in Childhood, 76, 219-226.

 

  1. Sowunmi, A., Gbotosho, G.O., Adedeji, A.A., Fateye, B.A., Sabitu, M.F., Happi, T.C. & Fehintola F.A. (2007). Effects of acute Plasmodium falciparum malaria on body weight in children in an endemic area.  Parasitology Research, 101, 343-349.

 

  1. Sowunmi, A., Gbotosho, G.O., Adedeji, A.A., Tambo, E., Bolaji, O.M., Happi, T.C. & Fateye B.A. (2008). Herpes simplex labialis in children with acute falciparum malaria.  Acta Tropica, 106, 68-71.

 

  1. Adedeji, A.A., Fehintola, F.A., Oladapo, N.O. & Sowunmi, A. (2008). Activities of artesunate and amodiaquine against intestinal helminth in children with Plasmodium falciparum malaria.  European Journal of Clinical Microbiology & Infectious Diseases. 27, 627-629.

 

 

Section 5  Diagnosis and epidemiology of malaria

  1. Salako, L.A., Ajayi, F.O., Sowunmi, A. & Walker, O. (1990). Malaria in Nigeria: a revisit.  Annals of Tropical Medicine & Parasitology, 84, 435-445.

 

  1. Walker, O., Sowunmi, A. & Salako, L.A. (1992). Pitfalls in the diagnosis of malaria: a-parasitaemic severe malaria.  Journal of Tropical Paediatrics, 38, 368.

 

  1. Sowunmi, A. & Akindele, J.A. (1993). Presumptive diagnosis of malaria in infants.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 87, 492.

 

  1. Happi, C.T., Gbotosho, G.O., Sowunmi, A., Falade, C.O., Akinboye, D.O., Oladepo, O. & Oduola, A.M.J. (2004). Malaria diagnosis: false positive parasightTM-F tests in falciparum malaria patients in Nigeria.  African Journal of Medicine & Medical Sciences, 33, 15-18.

 

  1. Gbotosho, G.O., Happi, C., Onikepe, F., Ochuko, K., Sowunmi, A. & Oduola A. (2010).  Rapid detection of lactate dehydrogenase and genotyping of Plasmodium falciparum in saliva of children with acute uncomplicated malaria.  American Journal of Tropical Medicine & Hygiene, 83, 496-501.

 

  1. Akindele, J.A., Sowunmi, A. & Abohweyere, A.E.J. (1993). Congenital malaria in a hyperendemic area: a preliminary report.  Annals of Tropical Paediatrics, 13, 273-276.

 

  1. Olowu, J.A., Sowunmi, A. & Abohweyere, A.E.J. (2000). Congenital malaria in a hyperendemic area: a revisit.  African Journal of Medicine & Medical Sciences, 29, 211-213.

 

  1. Sowunmi, A., Walker, O. & Salako, L.A. (1992). Hyperparasitaemia: not a reliable indicator of severity or poor prognosis in falciparum malaria in children from endemic African countries.  Annals of Tropical Paediatrics, 12, 155-158.

 

  1. Sowunmi, A., Ohaeri, J.U. & Falade, C.O. (1995). Falciparum malaria presenting as psychosis.  Tropical & Geographical Medicine, 47, 218-219.

 

  1. Sowunmi, A. & Akinbami, F.O. (1991). Body temperature in apparently healthy African children under 10 years of age. African Journal of Medicine & Medical Sciences, 20, 97-99.

 

  1. Sowunmi, A. (1995). Body temperature and malaria parasitaemia in African children.  East African Medical Journal, 72, 427-430.

 

  1. Jimmy, E.O., Saliu, I., Okpala, I., Walker, O., Sowunmi, A., Ademowo, G.O. & Essien. E.M. (1995). Effect of Plasmodium falciparum malaria on plasma Fibrinopeptide-A (FpA) concentration.  Central African Journal of Medicine, 41, 124-127.

 

  1. Sowunmi, A, Ogundahunsi, O.A.T., Falade, C.O., Gbotosho, G.O. & Oduola, A.M.J. (2000). Gastrointestinal manifestations of acute falciparum malaria in children.  Acta Tropica, 74; 73-76.

 

  1. Sowunmi, A., Walker, O. & Salako, L.A. (1993). Cerebral malaria in non-paediatric patients resident in southwestern Nigeria.  African Journal of Medicine & Medical Sciences, 20, 49-53.

 

  1. Sowunmi, A. (1994). Misdiagnosis of cerebral malaria in adolescents and adults in an endemic area.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 88, 493.

 

  1. Walker, O., Salako, L.A., Sowunmi, A., Thomas, J.O., & Sodeinde, O. (1992). Prognostic risk factors and post mortem findings in cerebral malaria in children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 86, 491-493.

 

  1. Sowunmi, A. (1993). Psychosis after cerebral malaria in children.  Journal of the National Medical Association, 85, 695-696.

 

  1. Sowunmi, A. (1997). Clinical study of cerebral malaria in African children.  African Journal of Medicine & Medical Sciences, 26, 9-11.

 

  1. Sowunmi, A., Akindele, J.A. & Balogun, M.A. (1995). Leukocyte count in falciparum malaria in African children from an endemic area.  African Journal of Medicine & Medical Sciences, 24, 145-149.

 

  1. Gbotosho, G.O., Okuboyejo, T.M., Happi, C.T. & Sowunmi, A. (2011).  Plasmodium falciparum hyperparasitaemia in Nigerian children:  epidemiology, clinical characteristics, and therapeutic responses to oral artemisinin-based combination treatments.  Asia Pacific Journal of Tropical Disease (2011), 85-93.

 

 

Section 6 Reversal of drug resistance in vitro and in vivo in Plasmodium falciparum

  1. Oduola, A.M.J., Omitowoju, G.O., Gerena, L., Kyle, D.E., Milhous, W.K., Sowunmi, A. & Salako, L.A. (1993). Reversal of mefloquine resistance with penfluoridol in isolates of Plasmodium falciparum from Southwest Nigeria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 87, 81-83.

 

  1. Oduola, A.M.J., Sowunmi, A., Milhous, W.K., Brewer, T., Kyle, D., Gerena, L., Rossan, R., Salako, L.A. & Schuster, B.G. (1998). In-vitro and in-vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine.  American Journal of Tropical Medicine & Hygiene, 58, 625-629.

 

  1. Sowunmi, A., Oduola, A.M.J., Ogundahunsi, O.A.T., Falade, C.O., Gbotosho, G.O. & Salako, L.A. (1997). Enhanced efficacy of chloroquine/chlorpheniramine combination in acute uncomplicated falciparum malaria in children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 91, 63-67.

 

  1. Sowunmi, A., Oduola, A.M.J., Ogundahunsi, O.A.T. & Salako, L.A. (1998). Enhancement of the antimalarial effect of chloroquine by chlorpheniramine in vivo.  Tropical Medicine & International Health, 3, 177-183.

 

  1. Sowunmi, A. & Oduola, A.M.J. (1997). Comparative efficacy of chloroquine/chlorpheniramine combination and mefloquine for the treatment of chloroquine-resistant Plasmodium falciparum malaria.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 91, 689-693.

 

  1. Sowunmi, A., Fehintola, F.A., Ogundahunsi, O.A.T. & Oduola, A.M.J. (1998). Comparative efficacy of chloroquine plus chlorpheniramine and halofantrine in acute uncomplicated falciparum malaria in Nigerian children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 92, 441-445.

 

  1. Sowunmi, A., Oduola, A.M.J., Ogundahunsi, O.A.T. & Salako, L.A. (1998). Comparative efficacy of chloroquine plus chlorpheniramine and pyrimethamine/sulphadoxine in acute uncomplicated falciparum malaria in Nigerian children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 92, 77-81

 

  1. Sowunmi, A., Adedapo, A.A., Fehintola, F.A., Sowunmi, C.O., Adedeji, A.A., Falade, A.G. & Oduola, A.M.J. (2000). Comparative efficacy and safety of two regimens of chlorpheniramine plus chloroquine in acute uncomplicated falciparum malaria in children.  Clinical Drug Investigation, 20, 317-325.

 

  1. Sowunmi, A., Fehintola, F.A., Adedeji, A.A., Falade, A.G., Falade, C.O., Akinyinka, O.O. & Oduola, A.M.J. (2000). Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children.  Annals of Tropical Medicine & Parasitology, 94, 209-217.

 

  1. Sowunmi, A. (2003). A randomized comparison of chloroquine and chloroquine plus ketotifen in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children.  Annals of Tropical Medicine & Parasitology, 97, 103-117.

 

  1. Sowunmi, A., Happi, T.C. & Oduola, A.M.J. (2004).  Reversal of chloroquine resistance in Plasmodium falciparum.  Journal of Applied Therapeutic Research, 5, 3-11.

 

  1. Oduola, O.O., Happi, T.C., Gbotosho, G.O., Ogundahunsi, O.A.T., Falade, C.O., Akinboye, D.O., Sowunmi, A. & Oduola, A.M.J. (2004).  Plasmodium berghei: efficacy and safety of combinations of chloroquine and promethazine in chloroquine-resistant infections in gravid mice.  African Journal of Medicine & Medical Sciences, 33, 77-81.

 

  1. Sowunmi, A., Fehintola, F.A., Adedeji, A.A., Gbotosho, G.O., Falade, C.O., Tambo, E., Fateye, B.A., Happi, T.C. & Oduola, A.M.J. (2004).  Open randomized study of pyrimethamine-sulfadoxine versus pyrimethamine-sulfadoxine plus probenecid for the treatment of uncomplicated Plasmodium falciparum malaria in children.  Tropical Medicine & International Health, 9, 606-614.

 

  1. Gbotosho, G.O., Ogundahunsi, O.A., Happi, C.T., Kyle, D.E., Gerena, L., Milhous, W., Sowunmi, A., Oduola, A.M.J. & Salako, L.A. (2006). The effects of alpha-1-acid glycoprotein on the potential clinical application of the reversal of chloroquine resistance phenomenon.  Annals of Tropical Medicine & Parasitology, 100, 571-578.

 

  1. Sowunmi, A., Gbotosho, G.O., Happi, C.T., Adedeji, A.A., Bolaji, O.M., Fehintola, Fateye, B.A. & Oduola, A.M.J. (2007). Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo.  Memorias do Instituto Oswaldo Cruz, 102, 417-419.

 

 

Section 7 Pharmacokinetics of antimicrobials and potential resistance reversing compounds

  1. Sowunmi, A., Rashid, T.J., Akinyinka, O.O. & Renwick, A.R. (1995). Ethnic differences in nifedipine kinetics: comparisons between Nigerians, Caucasians and South Asians.  British Journal of Clinical Pharmacology, 40, 489-493.

 

  1. Chukwuani, C.M., Coker, H.A., Oduola, A.M.J., Ifudu, N.D. & Sowunmi, A. (1998).  Single-dose pharmacokinetic study of ciprofloxacin and fleroxacin healthy adult Nigerian volunteers.  Chemotherapy, 46, 369-376.

 

  1. Chukwuani, C.M., Coker, H.A., Oduola, A.M.J., Sowunmi, A., & Ifudu, N.D. (2000).  Bioavailability of ciprofloxacin and fleroxacin:: results of a preliminary investigation in healthy adult Nigerian male volunteers..  Biological and Pharmaceutical Bulletin, 23, 968-972.

 

  1. Gbotosho, G.O., Happi, C.T., Sijuade, O.A., Ogundahunsi, O.A.T., Sowunmi, A. & Oduola, A.M.J. (2008).  Comparative study of interactions between chloroquine and chlorpheniramine or promethazine in healthy volunteers: a potential combination-therapy phenomenon for resuscitating chloroquine for malaria treatment in Africa.  Annals of Tropical Medicine & Parasitology, 102, 3-9.

 

  1. Oluwole, O.S.A., Onabolu, A.O. & Sowunmi, A. (2002).  Exposure to cyanide following a meal of cassava food.  Toxicology Letters, 135, 19-23.

 

 

Section 8. Development of new indices for measuring therapeutic efficacy of antimalarial drugs

  1. Sowunmi, A., Adedeji, A.A., Fehintola, F.A. & Oduola, A.M.J. (2000). Plasmodium falciparum kinetics during treatment with antimalarial drugs in children.  Clinical Drug Investigation, 20, 43-51.

 

  1. Sowunmi, A., Adedeji, A.A., Sowunmi, C.O., Falade, A.G., Sijuade, A.O. & Oduola, A.M.J. (2000). Comparative clinical characteristics and response to oral antimalarial therapy of children with and without Plasmodium falciparum hyperparasitaemia in an endemiic area.  Annals of Tropical Medicine & Parasitology, 94, 549-559.

 

  1. Sowunmi, A., Falade, A.G., Adedeji, A.A., Ayede, A.I., Fateye, B.A., Sowunmi, C.O. & Oduola, A.M.J. (2001). Comparative Plasmodium falciparum kinetics during treatment with amodiaquine and chloroquine in children.  Clinical Drug Investigation, 21, 371-381.

 

  1. Sowunmi, A., Falade, A.G., Adedeji, A.A., & Falade, C.O. (2001). Comparative clinical characteristics and responses to oral 4-aminoquinoline therapy of malarious children who did and did not develop 4-aminoquinoline-induced pruritus.  Annals of Tropical Medicine & Parasitology, 95, 645-653.

 

  1. Adedeji, A.A., Babalola, C.P. & Sowunmi, A., (2004). Clinical characteristics and kinetic indices of resistant Plasmodium falciparum during treatment with chloroquine in Nigerian children.  Journal of Applied Therapeutic Research, 5, 37-45.

 

  1. Sowunmi, A. & Oduola, A.M.J. (1998). Viability of  Plasmodium falciparum ex vivo: Comparison of the effects of artemether and sulfadoxine-pyrimethamine.  European Journal of Clinical Pharmacology, 54, 221-226.

 

  1. Sowunmi, A., Sowunmi, C.O., Adedeji, A.A. & Oduola, A.M.J. (2001). Comparison of artemether and artemether plus mefloquine in children with malaria and effects on viability of Plasmodium falciparum ex vivo.  Clinical Drug Investigation, 21, 33-40.

 

 

Section 9. Malaria-associated hepatomegaly and its kinetics

  1. Sowunmi, A. (1996). Hepatomegaly in acute falciparum malaria in children.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 90, 540-542.

 

  1. Sowunmi, A., Adedeji, A.A., Sowunmi, C.O., Falade, C.O., Falade, A.G., Ohaeri, B., Happi, T.C. & Oduola, A.M.J. (2001). Clinical characteristics and disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.  Annals of Tropical Medicine & Parasitology, 95, 7-18.

 

  1. Sowunmi, A. & Adedeji, A.A. (2002). The effects of chloroquine, amodiaquine and chloroquine plus chlorpheniramine on the disposition kinetics of the hepatomegaly associated with acute, uncomplicated, Plasmodium falciparum malaria in children.  Annals of Tropical Medicine & Parasitology, 96, 543-551.

 

  1. Sowunmi, A., Gbotosho, G.O., Adedeji, A.A., Tambo, E., Fateye, B.A., Happi, C.T., & Amoo, A.O.J. (2007).  The effects of artemether-lumefantrine vs amodiaquine-sulfalene-pyrimethamine on the hepatomegaly associated with Plasmodium falciparum malaria in children.  Parasitology Research, 100, 511–517.

 

 

Section 10. Gametocytaemia and antimalarial drugs

  1. Sowunmi, A. & Fateye, B.A. (2003).  Plasmodium falciparum gametocytaemia in Nigerian children: before during and after treatment with antimalarial drugs.  Tropical Medicine & International Health, 8, 783-792.

 

  1. Sowunmi, A. & Fateye, B.A. (2003). Asymptomatic, recrudescent, chloroquine-resistant, Plasmodium falciparum infections in Nigerian children: clinical and parasitological characteristics and implications for transmission of drug-resistant infections.  Annals of Tropical Medicine & Parasitology, 97, 469-479.

 

  1. Sowunmi, A., Fateye, B.A., Happi, T.C., Gbotosho, G.O. & Oduola, A.M.J. (2003). Plasmodium falciparum gametocytaemia in Nigerian children: peripheral immature gametocytaemia as indicator of a poor response to chloroquine treatment and its relationship to molecular determinants of chloroquine resistance.  Annals of Tropical Medicine & Parasitology, 97, 453-468.

 

  1. Sowunmi, A. & Fateye, B.A. (2003). Changes in Plasmodium falciparum gametocytaemia in children with chloroquine-sensitive asexual infections.  Parasite, 10, 363-369.

 

  1. Sowunmi, A. & Fateye, B.A. (2003).  Gametocyte sex ratios in children with asymptomatic, recrudescent, pyrimethamine-sulfadoxine-resistant, Plasmodium falciparum malaria.  Annals of Tropical Medicine & Parasitology, 97, 671-682.

 

  1. Sowunmi, A., Adedeji, A.A., Fateye, B.A. & Fehintola, F.A. (2004). Comparative effects of pyrimethamine-sulfadoxine, with or without probenecid, on Plasmodium falciparum gametocytes in children with acute, uncomplicated malaria.  Annals of Tropical Medicine & Parasitology, 98, 873-878.

 

  1. Sowunmi, A., Fateye, B.A., Adedeji, A.A., Fehintola, F.A. & Happi, T.C. (2004).  Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children.  Parasitology, 129, 255-262.

 

  1. Sowunmi, A., Adedeji, A.A., Fateye, B.A., & Babalola, C.P. (2004).  Plasmodium falciparum hyperparasitaemia in children: risk factors, treatment outcomes and gametocytaemia following treatment.  Parasite, 11, 317-323.

 

  1. Sowunmi, A., Fateye, B.A., Adedeji, A.A., Fehintola, F.A., Bamgboye, A.E., Babalola, C.P., Happi, T.C. & Gbotosho, G.O. (2005).  Effects of antifolates-cotrimoxazole and pyrimethamine-sulfadoxine on gametocytes in children with acute, symptomatic, uncomplicated, Plasmodium falciparum malaria.  Memorias do  Instituto Oswaldo Cruz, 100, 451-455.

 

  1. Adedeji, A.A., Fehintola, F.A., Fateye, B.A., Happi, T.C., Amoo, A.O.J. & Sowunmi, A. (2005). Plasmodium falciparum malaria in Nigerian children during high and low transmission seasons: Gametocyte carriage and response to oral chloroquine.  Journal of Tropical Pediatrics, 51, 288-294.

 

  1. Adedeji, Fateye, B.A., Amoo, A.O.J. & Sowunmi, A. (2006). Response to chloroquine treatment in children with or without gametocytes during uncomplicated Plasmodium falciparum malaria.  European Journal of Clinical Microbiology and Infectious Diseases, 25, 126-128.

 

  1. Sowunmi, A., Adedeji, A.A., Gbotosho, G.O., Fateye, B.A. & Happi, C. T. (2006). Effects of pyrimethamine-sulfadoxine, chloroquine plus chlorpheniramine, and amodiaquine plus pyrimethamine-sulfadoxine on gametocytes during and after treatment of acute, uncomplicated malaria in children.  Memorias do Instituto Oswaldo Cruz, 101, 887-893.

 

  1. Sowunmi, A., Balogun, T., Gbotosho, G.O., Happi, C.T., Adedeji, A.A., Fateye, B.A. & Fehintola F.A. (2007). Activities of amodiaquine, artesunate, and artesunate-amodiaquine against asexual- and sexual-stage parasites in falciparum malaria in children.  Antimicrobial Agents and Chemotherapy, 51, 1694-1699.

 

  1. Sowunmi, A., Balogun, T., Gbotosho, G.O., Happi, C.T., Adedeji, A.A., Bolaji, O.M., Fehintola F.A. & Folarin O.A. (2008). Activities of artemether-lumefantrine and amodiaquine-sulfalene-pyrimethamine against sexual-stage parasites in falciparum malaria in children.  Chemotherapy, 54, 201-208.

 

  1. Fehintola, F.A., Adedeji, A.A., Gbotosho, G.O., Happi, C.T., Balogun, S.T., Folarin, O.A., Sijuade, A. & Sowunmi, A.  (2008).  Effects of artesunate-cotrimoxazole and amodiaquine-artesunate against asexual and sexual stages of Plasmodium falciparum malaria in Nigerian children.  Journal of Infection & Chemotherapy, 14, 188-194.

 

  1. Sowunmi, A., Balogun, S.T., Gbotosho, G.O. & Happi, C.T. (2008).  Influence of anaemia on Plasmodium falciparum gametocyte sex ratios in acutely symptomatic children.  The Open Tropical Medicine Journal, 1, 13-20.

 

  1. Sowunmi, A., Balogun, S.T., Gbotosho, G.O. & Happi, C.T. (2008).  Plasmodium falciparum gametocyte sex ratios in children with acute uncomplicated symptomatic infection treated with amodiaquine.  Malaria Journal, 7:169.

 

  1. Sowunmi, A., Balogun, S.T., Gbotosho, G.O. & Happi, C.T. (2009).  Plasmodium falciparum gametocyte sex ratios in symptomatic children treated with antimalarial drugs.  Acta Tropica, 109, 108-117.

 

  1. Sowunmi, A., Gbotosho, G.O., Happi, C.T., Okuboyejo T.M., Folarin, O.A. & Balogun, S.T. (2009).  Population structure of Plasmodium falciparum gametocyte sex ratios in malarious children in an endemic area.  Parasitology International, 58, 438-443.

 

  1. Sowunmi, A., Nkogho, O.O., Okuboyejo, T.M., Gbotosho, G.O., Happi, C.T. & Adewoye, E.O. (2009).  Effects of mefloquine and artesunate mefloquine on the emergence, clearance and sex ratio of Plasmodium falciparum gametocytes in malarious children.  Malaria J, 8, 297.

 

  1. Gbotosho G.O., Sowunmi A., Okuboyejo, T.M., Happi, C.T., Michael, O.S., Folarin O.A., & Adewoye, E.O. (2011). Plasmodium falciparum gametocyte carriage, emergence, clearance, and population sex ratios in anaemic and non-anaemic malarious children.  Memorias do Instituto Oswaldo Cruz, 106, 562-569.

 

  1. Gbotosho G.O., Sowunmi A., Happi, C.T. & Okuboyejo, T.M. (2011). Plasmodium falciparum gametocyte carriage, sex ratios and asexual parasite rates in Nigerian children before and after a treatment protocol policy change instituting the use of artemisinin-based combination therapies. Memorias do Instituto Oswaldo Cruz, 106, 685-690.

 

  1. Gbotosho G.O., Sowunmi A., Happi, C.T. (2011). Kinetics of Plasmodium falciparum gametocyte sex ratios: Application to the evaluation of the potential of antimalarial drugs to influence malaria transmission. The Open Tropical Medicine Journal, 4, 33-38.

 

  1. Sowunmi A., Okuboyejo, T.M., Gbotosho, G.O. & Happi, C.T.  (2011). Risk factors for gametocyte carriage in uncomplicated falciparum malaria in children: before and after artemisinin-based combination treatments. Chemotherapy, 57, 497-504.

 

 

Section 11.  Predictors of antimalarial drug treatment failure and of hyperparasitaemia

  1. Sowunmi, A., Fateye, B.A., Adedeji, A.A., Fehintola, F.A., Gbotosho, G.O., Happi, T.C. & Oduola, A.M.J. (2005). Predictors of the failure of treatment with chloroquine plus chlorpheniramine, in children with acute, uncomplicated, Plasmodium falciparum malaria.  Annals of Tropical Medicine & Parasitology, 99, 331-338.

 

  1. Sowunmi, A., Fateye, B.A., Adedeji, A.A., Fehintola, F.A., Gbotosho, G.O., Happi, T.C., Tambo, E. & Oduola, A.M.J. (2005). Predictors of the failure of treatment with chloroquine in children with acute, uncomplicated, Plasmodium falciparum malaria, in an area with high and increasing incidences of chloroquine resistance.  Annals of Tropical Medicine & Parasitology, 99, 535-544.

 

  1. Sowunmi, A., Fateye, B.A., Adedeji, A.A., Gbotosho, G.O., Happi, T.C., Bamgboye, A.E., Bolaji, O.M. & Oduola, A.M.J. (2006). Predictors of the failure of treatment with pyrimethamine-sulfadoxine in children with uncomplicated, falciparum malaria.  Acta Tropica, 98, 6-14.

 

  1. Sowunmi, A., Gbotosho, G.O., Fateye, B.A., & Adedeji, A.A. (2006). Predictors of the failure of treatment with trimethoprim-sulfamethoxazole in children with uncomplicated, falciparum malaria.  Annals of Tropical Medicine & Parasitology, 100, 205-211.

 

  1. Sowunmi, A., Adewoye, E.O., Gbotosho, G.O., Happi, C.T., Sijuade, A., Folarin, O.A., Okuboyejo, T.M. & Michael, O.S. (2010).  Factors contributing to delay in parasite clearance in  uncomplicated falciparum malaria in children.  Malaria J, 9, 53.

 

  1. Sowunmi, A., Okuboyejo, T.M., Gbotosho, G.O. & Happi, C.T. (2011).  Risk factors for Plasmodium falciparum hyperparasitaemia in malarious children.  BMC Infectious Diseases, 11, 268.

 

  1. Sowunmi, A., Okuboyejo, T.M., Gbotosho, G.O. & Happi, C.T. (2012).  Early changes in Plasmodium falciparum asexual and sexual parasite populations in children with acute infections following treatment with artemisinin-based combination drugs.  Malaria Chemotherapy, Control & Elimination, 1, in press.  doi: 10.4303/mcce/235498

 

 

Section 12.  Molecular biology of antimalarial drug resistance and its relationship to in vivo drug response

  1. Happi, T.C., Gbotosho, G.O., Falade, C.O., Akinboye, D.O., Gerena, L., Hudson, T., Sowunmi, A., Kyle, D.E., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2003).  Point mutations in the pfcrt and pfmdr-1 genes of Plasmodium falciparum and clinical response to chloroquine among malaria patients from Nigeria.  Annals of Tropical Medicine & Parasitology, 97, 439-451.

 

  1. Happi, C.T., Gbotosho, G.O., Sowunmi, A., Falade, C.O., Akinboye, D.O., Hudson, T., Gerena, L., Kyle, D.E., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2004). Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria.  American Journal of Tropical Medicine & Hygiene, 70, 20-26.

 

  1. Happi, C.T., Gbotosho, G.O., Folarin, O.A., Sowunmi, A., Bolaji, O.M., Fateye, B.A., Kyle, D.E., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2006).  Linkage disequilibrium between two distinct loci in chromosomes 5 and 7 of Plasmodium falciparum and in vivo chloroquine resistance in Southwest Nigeria.  Parasitology Research, 100, 141-148.

 

  1. Folarin, O.A., Gbotosho, G.O. Sowunmi, A., Olorunsogo, O.O. & Happi, C.T. (2008).  Chloroquine resistant Plasmodium falciparum in Nigeria: relationship between Pfcrt and Pfmdr-1 polymorphism, in vitro resistance and treatment outcome.  The Open Tropical Medicine Journal, 1, 84-92.

 

  1. Happi, C.T., Gbotosho, G.O., Folarin, O.A., Bolaji, O.M., Sowunmi, A., Kyle, D.E., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2006).  Association between mutations in pfcrt and pfmdr1 genes and in vivo amodiaquine resistance in falciparum malaria-infected children in Nigeria.  American Journal of Tropical Medicine & Hygiene, 75, 155-161.

 

  1. Sowunmi, A., Balogun, S.T., Gbotosho, G.O. & Happi, C.T. (2008).  Some features of primary and recrudescent amodiaquine-resistant Plasmodium falciparum infections in Nigerian children.  Memorias Instituto do Oswaldo Cruz, 103, 754-759.

 

  1. Happi, T.C., Gbotosho, G.O., Folarin, O.A., Akinboye, D.O., Yusuf, B.O, Ebong, O.O., Sowunmi, A., Kyle, D.E., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2005).  Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine-pyrimethamine resistance in malaria-infected patients from Nigeria.  Acta Tropica, 95, 183-193.

 

  1. Happi, C.T., Gbotosho, G.O., Folarin, O.A., Milner, D., Sarr, O., Sowunmi, A., Kyle, D.E., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2006).  Confirmation of emergence of mutations associated with atovaquone-proguanil resistance in unexposed Plasmodium falciparum isolates from Africa.  Malaria Journal, 5, 82.

 

  1. Happi, C.T., Gbotosho, G.O., Folarin, O.A., Sowunmi, A., Hudson, T., O’ Neil, M., Milhous, W., Wirth, D.F. & Oduola, A.M.J. (2009).  Selection of Plasmodium falciparum multi-drug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.  Antimicrobial Agents & Chemotherapy, 53, 888-895.

 

  1. Gbotosho, G.O., Okuboyejo, T.M., Happi, C.T. & Sowunmi, A.  (2011).  Recrudescent Plasmodium falciparum infections in children in an endemic area following artemisinin-based combination treatments: implications for disease control.  Asia Pacific Journal of Tropical Disease 2011, 1-8.

 

  1. Gbotosho, G.O., Folarin, O.A, Bustamante, C., Pereira da Silva, L.H., Mesquita, E., Sowunmi, A., Zalis, M.G., Oduola, A.M.J. & Happi C.T. (2012).  Different patterns of pfcrt and pfmdr-1 polymorphisms in Plasmodium falciparum isolates from Nigeria and Brazil: the potential role of antimalarial drugs selection pressure.  American Journal of Tropical Medicine & Hygiene, 86, 211-213.

 

  1. Folarin, O.A., Bustamante, C., Gbotosho, G.O., Sowunmi, A., Zalis, M.G., Oduola, A.M.J. & Happi C. (2011). In-vitro amodiaquine resistance and its association with mutations in pfcrt and pfmdr-1 genes in Plasmodium falciparum isolates from Nigeria.  Acta Tropica, 120, 224-230.

 

  1. Bustamante. C., Folarin, O.A., Gbotosho, G.O., Batista, C.N., Mesquita, E.A., Brindeiro, R.M., Tanuri, A., Struchiner C.J., Sowunmi, A., Oduola, A., Wirth, D.F., Zalis, M.G., & Happi C.T. (2012). In-vitro reduced susceptibility to artemether in Plasmodium falciparum and its association with mutations polymorphisms in transporter genes.  Journal of Infectious Diseases, 206, 324-332.

 

 

Section 13.  Antimalarial drugs and malaria-associated anaemia

  1. Sowunmi, A., Balogun, S.T., Gbotosho, G.O. & Happi, C.T. (2009). Effects of amodiaquine, artesunate, artesunate-amodiaquine on Plasmodium falciparum malaria-associated anaemia in children.  Acta Tropica, 109, 55-60.

 

  1. Sowunmi, A., Gbotosho, G.O., Happi, C.T. & Fateye, B.A. (2009).  Factors contributing to anaemia in uncomplicated Plasmodium falciparum malaria in children.  Acta Tropica, 113, 155-161.

 

  1. Sowunmi, A., Gbotosho, G.O., Happi, C.T., Okuboyejo, T.M., Folarin, A.O. Balogun, S.T. & Michael, O.S. (2009).  Therapeutic efficacy and effects of artesunate-mefloquine and mefloquine alone on malaria-associated anemia in children with uncomplicated Plasmodium falciparum malaria in southwest Nigeria.  American Journal of Tropical Medicine & Hygiene, 81, 979-986.

 

  1. Sowunmi, A., Gbotosho, G.O., Happi, C.T., Folarin, O., Okuboyejo, T., Michael, O.S. & Fatunmbi, B. (2011). Use of area under the curve to evaluate the effects of antimalarials on malaria associated anemia.  American Journal of Therapeutics, 18, 190-197.

 

  1. Gbotosho, G.O., Sowunmi, A., Okuboyejo, T. & Happi, C.T. (2011). Fall in hematocrit per one thousand parasites cleared from peripheral blood: a simple method for estimating drug related fall in hematocrit following treatment of malaria infections. American Journal of Therapeutics, Epub ahead of print Oct 17.

 

 

Section 14.  Malaria and antimalarials during pregnancy

  1. Sowunmi, A., Oduola, A.M.J., Salako, L.A., Akindele, J.A., Omigbodun, A.O. & Omitowoju, G.O. (1993). Intramuscular sulphadoxine-pyrimethamine in chloroquine-resistant Plasmodium falciparum malaria during pregnancy.  Transactions of the Royal Society of Tropical Medicine & Hygiene, 84, 472.

 

  1. Sowunmi, A., Ilesanmi, A.O., Oduola, A.M.J., Omitowoju, G.O. & Ojengbede, O.A. (1996). Efficacy of mefloquine in uncomplicated chloroquine-resistant malaria during pregnancy.  Journal of Obstetrics & Gynaecology, 16, 362-363.

 

  1. Sowunmi, A., Abohweyere, A.E.J., Akindele, J.A., Ilesanmi, A.O, Falade, C.O. & Oduola, A.M.J. (1996).  Comparison of the incision and aspiration methods for the diagnosis of placental malaria infection.  Journal of Obstetrics & Gynaecology, 16, 316-320.

 

  1. Sowunmi, A., Ilesanmi, A.O., Akindele, J.A., Abohweyere, A.E.J., Fawole, A.O., Falade, C.O. & Oduola, A.M.J. (1996).  Placental falciparum infection and outcome of pregnancy in Nigerian mothers from an endemic area.  Journal of Obstetrics & Gynaecology, 16, 211-216.

 

  1. Sowunmi, A., Oduola, A.M.J, Ogundahunsi, O.A.T., Fehintola, F.A. & Arowojolu, A.O. (1998). Efficacy of chloroquine plus chlorpheniramine in acute uncomplicated chloroquine-resistant malaria during pregnancy: a preliminary study.  Journal of Obstetrics Gynaecology, 18, 524-527.

 

  1. Sowunmi, A., Oduola, A.M.J, Ogundahunsi, O.A.T., Fehintola. F.A. Ilesanmi, A.O. Akinyinka, O.O. & Arowojolu, A.O. (1998). Randomised trial of artemether versus artemether and mefloquine for the treatment of chloroquine and/or sulfadoxine-pyrimethamine-resistant falciparum malaria during pregnancy.  Journal of Obstetrics & Gynaecology, 18, 324-329.

 

  1. Sowunmi, A. (2002). Malaria during pregnancy. In: Contemporary Obstetrics and Gynaecology in Developing Countries. Ed. Okonofua F.E. pages 368-377. Womens Health and Action Research Centre Press.

 

 

Section 15.  In vitro antiplasmodial activities of natural products

  1. Abiodun O.O., Gbotosho, G.O., Ajaiyeoba, E.O., Happi, C.T., Hofer, S., Wittin, S., Sowunmi, A., Brun, R., & Oduola A.M.J. (2010).  Comparison of SYBR Green1-PicoGreen- and (3H) hypoxanthine-based assays for in vitro antimalarial screening of plants from Nigerian ethnomedicine  Parasitology Research 106, 933-939.

 

  1. Abiodun O., Gbotosho, G, Ajaiyeoba, E., Happi, T., Falade, M., Wittin, S., Sowunmi, A., Brun, R., & Oduola A. (2011).  In vitro antiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicie.    Pharmaceutical Biology 49, 9-14.

 

 

Section 16.  General Medicine

  1. Akinbami, F.O. & Sowunmi, A. (1991). Body temperature in the Nigerian neonate- comparison of axillary and rectal temperatures.  Afr J Med Med Sci 20, 49-52.

 

  1. Iyun, A.O. & Sowunmi, A. (1986). Clinical experience with captopril-nadolol-thiazide combination in the management of refractory hypertension.  Clinical Trials  5, 11-16.

 

  1. Iyun, A.O. & Sowunmi, A. (1988). Clinical experience with minoxidil and nadolol in the management of refractory hypertension.  West Afr J Med 7, 205-208.

 

  1. Ahaneku, J.E., Taylor, G.O., Agbedana, E.O., Walker, O., Sowunmi, A. & Salako, L.A. (1992). Effects of amlodipine on plasma lipid and lipoprotein levels in hypertensive patients.  J Intern Med 232, 489-491.

 

  1. Ahaneku, J.E., Taylor, G.O., Walker, O., Agbedana, E.O., Sowunmi, A. & Salako, L.A. (1994). Biochemical changes during amlodipine treatment in hypertensive patients.  Eur J Clin Pharmacol 46, 249-251.

 

  1. Ahaneku, J.E., Taylor, G.O., Agbedana, E.O., Walker, O., Sowunmi, A. & Salako, L.A. (1996). Biochemical changes during a cross-over treatment of doxazocin, moduretic and amlodipine in hypertensive patients.  J Pak Med Assoc 46, 71-73.

 

  1. Sowunmi, A., Salako, L.A. & Walker, O. (1996). Open trial of doxazosin in hypertensive Africans: dose finding, efficacy and safety studies.  Afr J Med Med Sci 25, 53-59.

 

  1. Sowunmi, A., Walker, O. & Salako, L.A. (1996). Amlodipine as a monotherapy in hypertensive Africans: clinical efficacy and safety studies.  Afr J Med Med Sci 25, 213-216.

 

  1. Akinyinka, O.O., Sanni, K.A., Falade, A.G., Akindele, M.O. & Sowunmi, A. (1999).  Arm area measurement as indices of nutritional reserves and body water in African newborns.  Afr. J Med Med Sci 28, 5-8.

 

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